In-Situ Liquid Phase Transmission Electron Microscopy: A Powerful Technique for Life Science Applications

Originally Aired:

Date: September 7, 2022


During this talk, Hugo will introduce our advanced technology for in situ LPEM, namely the DENSsolutions Stream system: a plug-and-play system that uses a micro-electromechanical system (MEMS) device as a smart sample carrier.

With Stream, you can perform in situ LPEM studies under sub-nanometer resolution, while keeping your bio-sample in its native liquid environment. This unlocks the possibility to observe biological processes as they truly occur as a function of different stimuli.

Similarly, you can control the biochemistry on-the-fly and influence the kinetics of a biochemical reaction, while avoiding the liquid-air interface. Moreover, the system enables high-throughput studies and the possibility to re-collect the sample for downstream biochemical analysis.

As a result, research areas such as single particle analysis, in-vivo studies of protein-protein interactions, virology, extracellular vesicles, drug delivery, and pharmaceutical design are certainly some of the many fields where Stream can play a critical role.

Presentation By:

Dr. Hugo Perez Garza
Hugo Perez-Garza, Ph.D.
Chief Executive Officer
DENS Solutions

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