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Medical Design & Manufacturing West 2024  | Feb. 6-8, 2024 | Anaheim, CA

MD&M West – Medical Design & Manufacturing West

Nanoscience Instruments and our sister company, Nanoscience Analytical, provide cutting-edge instrumentation and process development services to enhance the production of medical devices and biomedical products such as tissue scaffolds, vascular grafts, wound healing therapeutics, and more.

Visit us in Booth #547 to learn about the power and versatility of the electrospinning technique and discover all our solutions for medical device development and manufacturing. We will be running live demonstrations of our advanced electrospinning equipment and offering test drives of the best-selling desktop SEM to visualize the microstructure of the nanofiber samples. Our team of experts look forward to discussing how adding this technology to your lab will help you achieve your production goals!

For FREE MD&M Expo passes, sign up via our custom link!

Expo Hours

November 6-8, 2024:
Tuesday: 9 am – 5 pm
Wednesday: 9 am – 5 pm
Thursday: 8 am – 4 pm

Location

Booth #547
Anaheim Convention Center
800 W Katella Ave
Anaheim, CA 92802

Attend Our Technical Presentation:

Room 201ABCD | Feb 6th | 4:45 – 5:15 pm

Controlled Release Via Polymeric Sintered Electrospun Capsules with Nanoscale Porosity

Presented by:
Dr. Francisco J Chaparro

Fluidnatek Product Manager, Nanoscience Instruments

Visit the accompanying poster on the Mezzanine level of the Anaheim Convention Center throughout the conference to see the data behind the presentation!

Introduction: Drug delivery vehicles made through extrusion or film formation are frequently used to control drug release rates. While effectiveness can be limited based on the drug size, incorporation of porogens can improve release rates. Implementing porogens to achieve nanoscale pores can be challenging, as traditional techniques often result in pores larger than the nanoscale, leading to biphasic drug delivery. Incorporating salts into polymer solutions used for electrospinning offers an aternative approach to generate nanoscale porosity onto sintered electrospun capsules for controlled drug delivery.

Methods: Electrospun polycaprolactone (PCL):polyethylene terephthalate (PET):HEPES salt (70:10:20, 80:10:10, 85:10:5 and 88:10:2) fibers were generated using a Fluidnatek LE-100 unit . Following our previous work, samples were electrospun onto 3 mm rods and sintered at 100°C for 3 h under vacuum to form dense specimens. After being removed from the rod, salts were leached out in water, samples were then sealed with a model drug (rose bengal, RB) and oil carriers (hydrophobic and hydrophillic) to form closed capsules. Microstructure, water uptake, mechanical properties and RB release were studied.

Results: Nanoscale pores were observed on electrospun and sintered capsules post-water treatment. Pore size and interconnectivity varied depending on HEPES content with more interconnectivity at higher initial salt loading. Water uptake over 49 days showed no water uptake when a hydrophobic oil was used. Meanwhile, depending on the type of hydrophillic oil used, water uptake increased either 15% or 30% of the initial capsule weight. Salt incorporation to fibers and films (PCL:PET:HEPES, 80:10:10) increased ultimate tensile strength (UTS) by 4- and 2-folds, respectively, when compared to PCL:PET from our previous work. RB release from capsules following salt removal and using a hydrophillic oil as the carrier showed zero-order in vitro delivery over 10 days. Obtained release rates were 6.87 ± 0.23, 10.56 ± 0.09, 33.81 ± 0.56 and 60.73 ± 1.34 μg day-1 for 88:10:2, 85:10:5, 80:10:10 and 70:10:20 PCL:PET:HEPES, respectively.

Conclusions/Impact: The inclusion of soluble salts in polymeric solutions is a promising approach for creating nanoscale porosity in electrospun fibers. Following densification and post-salt leaching, we can enhance the porosity and interconnectivity of the resulting capsules. These sintered vehicles have the potential to improve drug loading, as they can be tailored to different sizes and can use various carriers to enhance water uptake and drug delivery.

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