QSenseTM instruments enable real-time measurement of mass and viscoelastic properties at surfaces, allowing for quantification of molecular adsorption, desorption, and structural properties.

Use QSense QCM-D to measure:

How Much

Nanoscale mass changes in real-time

How Fast

Time-resolved kinetics data with 5 millisecond resolution

What Process

Degradation, cross-linking, swelling/collapse, and conformational changes of surfaces

What Structure

Layer thickness and viscoelastic properties

QSense Quartz Crystal Microbalances with Dissipation enable analysis of molecular interactions and surface properties in real-time. Based on established and powerful quartz crystal microbalance technology, QSense gives you vast exploration and experimentation capabilities making it easy for you to find answers to your research questions.

The unique dissipation parameter is obtained under non-voltage conditions. With this technique, you can obtain accurate measurements faster for a wide range of samples, including aqueous as well as organic solvent systems.

Key Features of the QSense Instruments

Superior accuracy

QCM-D gives you real-time molecular analysis of mass with nanogram precision while also detecting structural changes and solvent content. The result: accurate outcomes and high reproducibility across experiments.

Experimental versatility

QSense instruments are designed to enable experiments with varied measurement conditions such as: temperature, pressure, and humidity. With precisely tuned conditions, a wide variety of samples in liquid or air can be analyzed. It also offers the broadest sensor surface assortment on the market.

As easy as it gets

Turn-key instruments, intuitive software, and support from our experienced applications team will ensure that you get the most out of your measurements. Our analytical team can also support your research through contract R&D, proof-of-concept studies, and process development.

World Leader in Analyzing Molecular Interactions

The quartz crystal microbalances from Biolin Scientific have earned trust in labs all over the world. With more than 2000 publications worldwide, QSense has enabled the analysis of interfaces, thin-films, and molecular interactions. Through long-term development and experience, the advanced measurement techniques of these instruments have earned a reputation of precision in several industries.

QSense Models

QSense Pro

Fully automated for large scale analysis

Qsense Pro Instrument

QSense Analyzer

Fast sample processing at high quality

QSense Explorer

Versatile and modular for quantification at research laboratories

QSense Initiator

The superior QCM with Dissipation monitoring technology

Compare Models

QSense ModelProAnalyzerExplorerInitiator
Sensors and sample handling system
Number of Sensors8 (4 parallel in flow)411
Volume above each sensor~ 15 μl~ 40 μl~ 40 μl~ 40 μl
Minimum sample volume~ 50 μl~ 200 μl~ 200 μl~ 200 μl
Working temperature ± 0.02 *A4-70 °C15-65 °C15-65 °C20-45 °C
Minimum dispense volume1μl*
SensorsGold, SiO2, Ti and other metals, oxides, nitrides, steels, glasses, polymers, etc.Gold, SiO2, Ti and other metals, oxides, nitrides, steels, glasses, polymers, etc.Gold, SiO2, Ti and other metals, oxides, nitrides, steels, glasses, polymers, etc.Gold, SiO2, Ti and other metals, oxides, nitrides, steels, glasses, polymers, etc.
Measurement Characteristics
Time resolution> 200 data points per second> 100 data points per second> 100 data points per second2 data points per second
Maximum mass sensitivity in liquid~ 0.5 ng/cm2 C~ 0.5 ng/cm2 C~ 0.5 ng/cm2 C
Normal mass sensitivity in liquid~ 1.8 ng/cm2 F~ 1.8 ng/cm2 F~ 1.8 ng/cm2 E~ 1.8 ng/cm2
Maximum dissipation sensitivity in liquid~ 0.04 x 10-6 C
~ 0.04 x 10-6 C
~ 0.04 x 10-6 C
Normal dissipation sensitivity in liquid~ 0.1 x 10-6 F~ 0.1 x 10-6 F~ 0.1 x 10-6 E~ 0.1 x 10-4
Analysis softwareQSense DfindQSense DfindQSense Dfind
Output parametersFrequency, dissipation, modeled values of mass, thickness, and viscoelasticity.Frequency, dissipation, modeled values of mass, thickness, and viscoelasticity.Frequency, dissipation, modeled values of mass, thickness, and viscoelasticity.Frequency, dissipation, Sauerbrey mass
Electronics unit
(HxWxL in cm)
Chamber (HxWxL in cm)70x67x5712x23x345x10x155x10x15
Learn MoreProAnalyzerExplorerInitiator

A The temperature stability depends on variations in how the ambient temperature affects the warming or cooling of the chamber.
B Smallest sample volume to pick up and dispense. Note that the smallest volume needed for measurement is 50 µl.
C Data from one sensor in single frequency mode. One data point collected every 5 seconds. The Sauerbrey relation is assumed to be valid.
E Data from multiple frequency modes (all harmonics). Four data points are collected within 1 second. The Sauerbrey relation is assumed to be valid.
F Data from all sensors in multiple frequency modes (all harmonics) are collected within 1 second. The Sauerbrey relation is assumed to be valid.

All specifications are subject to change without notice.

QSense DFind

QSense DFind is the reliable and easy-to-use analysis software from QSense. It helps you to quickly and simply extract the information you are looking for, such as mass, thickness, viscoelastic properties, and adsorption rates.

Key Features of QSense DFind Software

QuickView and AutoPlotting to review and compare results

Material library and Model fit traffic lights

SmartTools analysis method toolbox

Batch mode and template tool

Report tool

All data treatment and analysis tools in one unified program

QSense DFind is a comprehensive analysis program with an intuitive graphical interface that helps users efficiently quantify, compile, and compare data throughout experiments. DFind simplifies the process from raw data reviewing, through modeling, to the information extraction, and the final report.

Exploit the full potential of the information in your data

QSense Dfind helps you unveil and extract all the relevant information embedded in your data. In addition to the software assisted modelling of mass and viscoelastic parameters, QSense Dfind supports a range of qualitative and quantitative analysis methods.

Analyze all your data in one go

Equipped with a powerful analysis engine, QSense DFind boosts efficiency by enabling simultaneous analysis of multiple data sets. Use DFind to organize projects, share favorite templates with colleagues, and keep track of important experiments and tools.

A QCM-D Sensor for every application

To purchase QSensors please visit our webstore:

Our quality – your research success

QSense takes pride in the extensive range of high quality sensors developed and produced in our world class in-house facilities. When you buy QSensors, they are quality tested to ensure reliability and quality guaranteed for QCM-D studies.

Get the most out of your time spent planning and executing experiments.

Our wide range – your possibilities

QSense standard collection of QSensors contains a wide range of materials such as basic elements, polymers, steels, functional surfaces, and much more to accommodate your application needs.

Find the right sensor for your application – from molecular and medical sciences, to environmental sciences, oil and gas, and detergent and cleaning research.

QSensors & Add-Ons

Read more about the full range of QSense Modules and QSensors.

Explore the list of coating materials to discover your research possibilities.

QSensor Specifications

CategoryQSensor Specification
Basic ElementsAluminum, cobolt, chromium, copper, Gold, Iridium, Magnesium, Molybdenum, nickel, Palladium, Platina, Silica, Silver, tantalum, titanium, tungsten, Zirconium
OxideSilicon dioxide, rough Silicon dioxide, aluminium oxide, Iron oxides, Zirconium Silver oxide, Magnesium oxide, titanium dioxide, Indium-tin oxide.
NitridesTantalum nitride, Silicon nitride, titanium nitride
CarbidesIron carbide, Silicon oxycarbide, Silicon carbide
SulfidesCopper sulfide, Iron sulfide, nickel sulfide, Zinc sulfide
PolymersPolystyrene, amorphous flouropolymer 1600 (teflon® like), nylon, Polyethyleneterephtalate, Polyurethane, Polymethylmetacrylate, Polyvinylidenediflouride, Polyiminoethylene
FunctionalizedBiotin, His-tag capturing
GlassesBorosilicate, Soda-lime, Lead
Steels & AlloysSS2343, L605 Steel, SS2348, cobalt-chromium-tungsten-nickel-manganese alloy, nickel-chromium alloy
OtherHydroxyapatite, au with ti-adhesion, cellulose, aluminum silicate, Barium titanate, calcium phosphate, aluminum silicate, rough Gold, calcium carbonate.
Sensor Specifications
Frequency4.95 MHz +/- 50 kHz
Electrode Layer40 nm – 1 μm
SizeDiameter: 14 mm, thickness: 0.3 mm
FinishOptically polished, surface roughness of electrode less than 3 nm (RMS)
* Please note: New coatings are regularly added, contact us for more information.

QSense System Modules

Flow Module

Ideal for standard liquid-based mass sensing measurements

Teflon Flow Module

Suitable for when reagents or molecules are sensitive to interactions with titanium

Open Module

Designed to enable pipetting of sample directly onto the sensor surface

Humidity Module

Measures vapor uptake and release from thin films coated on the sensor

QSense Simultaneous Technique Enabling Modules

Electrochemistry Module

Allows simultaneous QCM-D electrochemistry or QCM-D/EIS measurements

Electrochemistry Window Module

Combine QCM-D & EQCM-D with microscopy, or perform light-sensitive EC experiments combined with QCM-D

QCM-D QWEM-401 Electrochemistry Window Module

Window Module

Enables experiments with UV-induced reactions and combination with fluorescence detectors

Ellipsometry Module

Enables simultaneous QCM-D and ellipsometric measurements on the same substrate

High Temperature Chamber

Allows for stagnant or flow measurements at an extended temperature interval up to 150 ºC

ALD Holder

Enables QCM-D measurements at pressures different from the ambient gas phase

Biolin Scientific
QCM-D High Pressure Chamber System
Quartz crystal microbalance with dissipation high pressure and temperature chamber

Explore Real-life Conditions

QSense provides a unique solution for you to understand the surface interactions of oil components, additives and other relevant chemicals in real-time.

QSense High Pressure gives you the additional possibility to explore more with experiments closer to real-life conditions. Whether you are struggling to increase oil yield, prevent fouling of pipes, or find an optimal lubricant for engines, it is valuable to understand your processes better.

With QSense High Pressure you can make smarter decisions based on information about the real-life surface interaction processes.



Flow Assurance: Prevent Fouling

Fouling and clogging of pipes can be a costly problem. Added chemicals are commonly used for flow assurance.

Examine fouling processes to find methods or additives to minimize the problem. Use carbon steel sensors to mimic the surface of pipelines and study adsorption and release of crude oil/asphaltenes under different conditions. Experiment with chemical composition, surface material, prressure and temperature.

Oil Recovery: Enhanced Oil Recovery

Extraction of oil from underground reservoirs or tar sands require carefully considered process conditions. Use scientific analysis to find your way to optimize.

The use of polymers and surfactants can change the viscosity of the injected water and the wettability of the rock to dissolve oil from the mineral. Measure the adsorption of polymers or surfactants and the release of oil from a mineral sensor to optimize your chemical solutions and increase your yield. Less surfactants used gives a more environmentally friendly solution and reduces costs.

Oil Recovery: Bitumen Liberation

Extracting bitumen from oil sands can be difficult. A silica sensor coated with bitumen can simulate the oil sand and enable analysis of the bitumen liberation process.

Study the bitumen detachment to find the optimal conditions of e.g. pH and temperature to maximize the recovery.

Fuels and Lubricants: Optimize Engine Lubricants

Lubricants are used in numerous applications to control friction and increase the lifespan of moving parts. These fluids consist of a variety of surface active chemistries competing for the surface.

Understanding the nature of adsorption of surface active chemicals is key to finding a well-balanced lubricant. Study the effect of fuel and lubricant additives in engines with a stainless steel sensor. Observe the adsorption in real-time to find the delicate balance of chemicals for optimal performance.

CategoryQSense High Pressure Chamber Specification
Number of sensors1
Minimum sample volume~50 μl
Temperature range, +/- 0.02 °C4 – 150 °C
Pressure range90 – 200 bar
Time resolution0.005 s
Quantification of mass, viscoel. propYes
Learn MoreView full specifications

Learn more about QSense QCM-D:

Quartz Crystal Microbalance and QCM-D Technique: Read about the theory, instrumentation, and operating methods.

QCM-D Webinars: OnDemand access to our collection of QCM-D related webinars hosted by our team of application scientists.

QCM-D Application Notes: Learn more about how QCM-D technology can answer your research questions.

Monitoring therapeutic protein interactions with QSense QCM-D: Explore our collection of application notes, webinars, and more, all focused on applications of QCM-D in the development of therapeutic protein drugs.

Frequently Asked Questions about QSense QCM-D

What is the difference between QCM and QCM-D?

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