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Controlled Release Society | July 24-28, 2023 | Las Vegas, NV

Controlled Release Society 2023 Annual Meeting

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Nanoscience Instruments/Nanoscience Analytical provide instrumentation and process development solutions that satisfy the R&D demands of drug delivery applications. Visit Booth #404 to witness how our ISO-certifiable electrospinning equipment enables encapsulation of APIs or creation of biomimetic structures including grafts and tissue scaffolds. Afterwards, characterize the products with our automated scanning electron microscope (SEM).

When

July 24-28, 2023
Tues: 7:00-9:00 PM
Wed:  8:00 AM-9:00 PM
Thurs: 8:00 AM-6:00 PM

Where

Booth #404
Paris Hotel
3655 S Las Vegas Blvd
Las Vegas, NV 89109

Visit Our Poster:

Controlled Release From Sintered Electrospun Capsules with Nanoscale Porosity

Presented by:
Dr. Francisco J Chaparro

Fluidnatek Product Manager, Nanoscience Instruments

Visit Our Poster | Poster #677

Tuesday, July 25: 7-9pm
Wednesday, July 26: 10-11am, 1-2pm, 6:30-8:30pm
Thursday, July 27: 10-11am, 1-2pm, 5-6pm

Title: Controlled Release from Sintered Electrospun Capsules with Nanoscale Porosity
Biography: Francisco J. Chaparro works at Nanoscience Instruments as the Electrospinning Product Manager. He received his PhD in Materials Science & Engineering from The Ohio State University working under Dr. John J. Lannutti.

Introduction: Drug delivery vehicles made through extrusion or film formation are frequently used to control drug release rates. While effectiveness can be limited based on the drug size, incorporation of porogens can improve release rates. Implementing porogens to achieve nanoscale pores can be challenging, as traditional techniques often result in pores larger than the nanoscale, leading to biphasic drug delivery. Incorporating salts into polymer solutions used for electrospinning offers an aternative approach to generate nanoscale porosity onto sintered electrospun capsules for controlled drug delivery.

Methods: Electrospun polycaprolactone (PCL):polyethylene terephthalate (PET):HEPES salt (70:10:20, 80:10:10, 85:10:5 and 88:10:2) fibers were generated using a Fluidnatek LE-100 unit . Following our previous work, samples were electrospun onto 3 mm rods and sintered at 100°C for 3 h under vacuum to form dense specimens. After being removed from the rod, salts were leached out in water, samples were then sealed with a model drug (rose bengal, RB) and oil carriers (hydrophobic and hydrophillic) to form closed capsules. Microstructure, water uptake, mechanical properties and RB release were studied.

Results: Nanoscale pores were observed on electrospun and sintered capsules post-water treatment. Pore size and interconnectivity varied depending on HEPES content with more interconnectivity at higher initial salt loading. Water uptake over 49 days showed no water uptake when a hydrophobic oil was used. Meanwhile, depending on the type of hydrophillic oil used, water uptake increased either 15% or 30% of the initial capsule weight. Salt incorporation to fibers and films (PCL:PET:HEPES, 80:10:10) increased ultimate tensile strength (UTS) by 4- and 2-folds, respectively, when compared to PCL:PET from our previous work. RB release from capsules following salt removal and using a hydrophillic oil as the carrier showed zero-order in vitro delivery over 10 days. Obtained release rates were 6.87 ± 0.23, 10.56 ± 0.09, 33.81 ± 0.56 and 60.73 ± 1.34 μg day-1 for 88:10:2, 85:10:5, 80:10:10 and 70:10:20 PCL:PET:HEPES, respectively.

Conclusions/Impact: The inclusion of soluble salts in polymeric solutions is a promising approach for creating nanoscale porosity in electrospun fibers. Following densification and post-salt leaching, we can enhance the porosity and interconnectivity of the resulting capsules. These sintered vehicles have the potential to improve drug loading, as they can be tailored to different sizes and can use various carriers to enhance water uptake and drug delivery.
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