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ACS Colloid and Surface Science Symposium 2023  | June 4-7, 2023 | Raleigh, NC

97th ACS Colloid & Surface Science Symposium

Mark your calendar for the 97th ACS Colloid and Surface Science Symposium and make sure to visit us during the event. This symposium will be held at the renowned McKimmon Conference and Training Center, located on the beautiful campus of North Carolina State University in Raleigh, NC. The event promises to be an unparalleled gathering of researchers, scholars, and professionals from around the world, focusing on the cutting-edge advancements in the field of colloid and surface science.

During the symposium, you will have the opportunity to immerse yourself in a vibrant atmosphere brimming with intellectual exchange and innovative insights. With over 400 oral and poster research presentations scheduled, including two inspiring plenary lectures, two captivating award lectures, and the recognition of exceptional PhD students, the event is set to be a hub of knowledge and inspiration.

Come visit the Nanoscience Instruments booth for a live QCM-D demonstration on the brand-new QSense Omni!

Expo Hours

June 5-7, 2023:
Monday
: 8 am – 5 pm 
Tuesday: 8 am – 5 pm 
Wednesday: 8 am – 3 pm 

Location

Table #3
McKimmon Conference & Training Center, NCSU
1101 Gorman St
Raleigh, NC 27606

Attend Our Presentation:

Surface-induced aggregation of monoclonal antibody – using QCM-D to investigate mechanism of surfactant effect

Presented by:
Dr. Archana Jaiswal

Product Manager QSense, Nanoscience Instruments

Tuesday, June 6th | Afternoon Session II | 4:20pm | Room 3

The use of protein therapeutics is increasing due to their potential in the treatment of chronic diseases and cancer. Monoclonal antibodies are the primary class of proteins used due to their capacity to be precisely modified to a specific target. One of the main challenges with protein therapeutic production is the production costs. Therefore, precise control of the interaction between the produced antibodies and materials used in production, storage and administration is of high value to avoid unwanted adsorption and aggregation. Such materials can be glass, polymers and metals in concentrators, tubing, containers, or bags.

In this study, we used quartz crystal microbalance with dissipation monitoring (QCM-D) to study the adsorption of monoclonal antibodies and lysozyme on stainless steel, borosilicate glass, polystyrene, PVDF and PTFE. The effect of the excipient polysorbate-20 (PS20) on the adsorption and desorption was also studied. PS20 could be seen to lower the adsorption of protein to PVDF and polystyrene but not to the same extent for stainless steel and borosilicate glass. The amount of adsorbed protein was also higher for stainless steel and borosilicate.

Conventional techniques to study aggregation, e.g. dynamic light scattering or microscopy, can detect aggregates once they are formed in higher concentration. In contrast, by using QCM-D we could in real-time quantify the amount of adsorbed protein at the nanogram level and detect changes in viscoelastic properties. QCM-D can therefore provide valuable insight into the mechanisms of initial adsorption and further aggregation behavior not easily obtained by other methods.


Monitor surface interactions and biomolecular processes in situ using QCM-D with a vast assortment of surface material options, including custom sensor surfaces
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