BioNavis MP-SPR
MP-SPR Navi 200 OTSO
entry level 2 channel system
The MP-SPR Navi™ 200 OTSO is a modular, entry-level Multi-Parametric Surface Plasmon Resonance (MP-SPR) system designed for real-time, label-free analysis of molecular interactions and thin film characterization. Its open architecture makes it ideal for integration with auxiliary instrumentation, enabling customized experimental workflows and advanced research applications. The accessible design also makes the system well suited for teaching laboratories and method development. Featuring a two-channel configuration with support for up to four measurement wavelengths, the MP-SPR Navi™ 200 OTSO provides a flexible platform for a wide range of surface science and biosensing applications.
2 Channels, 4 Wavelengths
Simultaneously measure in 2 channels on one sensor. Use up to 4 different wavelengths in each channel
Layer Properties
Measure thickness and characterize refractive index of films, from Angstroms to several micrometers
Add on Modules
Complement with electrochemical, high chemical resistant, cell, fluorescence and gas flow modules
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entry level 2 channel system
The MP-SPR Navi™ 200 OTSO is a modular, entry-level Multi-Parametric Surface Plasmon Resonance (MP-SPR) system designed for real-time, label-free interaction analysis and thin film characterization. Engineered for ease of use, it combines intuitive software with simplified sensor handling to streamline experiment setup and data acquisition. Its open architecture allows seamless integration with complementary analytical instruments, making it an ideal platform for customized research workflows and method development. As research needs evolve, the system can be easily upgraded with an automated liquid handling system to increase throughput, improve reproducibility, and support more advanced experimental protocols.
Application Areas:
MP-SPR Navi 200 OTSO
Product Features
Angular scanning mode
The MP-SPR Navi™ 200 OTSO employs a true goniometric Surface Plasmon Resonance (SPR) configuration with a rotating detector to perform angular scanning, known as MP-SPR mode. Instead of measuring at a single angle, the system scans across a wide angular range of 40° to 78°, capturing the complete SPR curve with an exceptional angular resolution of 0.001°. This comprehensive measurement provides access to multiple analytical parameters beyond those available with conventional SPR systems, enabling more detailed characterization of molecular interactions and thin films. Typical sampling rates are less than two seconds, depending on the selected angular range and resolution, allowing rapid, real-time monitoring of dynamic surface processes.
Laser Wavelengths
The MP-SPR Navi™ 200 OTSO is equipped with a 670 nm laser as standard, enabling high-sensitivity measurements across both flow channels. For advanced applications, each channel can be configured with multiple wavelengths, including dual-laser (670 nm and 785 nm), triple-laser (670 nm, 785 nm, and 980 nm), or quad-laser (670 nm, 785 nm, 850 nm, and 980 nm) configurations. The additional laser wavelengths provide multi-wavelength MP-SPR measurements that enable the detection of molecular conformational changes and the characterization of thin film properties, including layer thickness, refractive index, and structural evolution, extending the system beyond traditional interaction analysis. This feature is critical in applications involving layer characterization, live cell studies, and extracellular vesicle size and concentration analysis.
Liquid handling
The MP-SPR Navi™ 200 OTSO features two independent flow channels and a manual sample injector for flexible, low-volume sample introduction. As laboratory throughput requirements increase, the system can be easily upgraded with a dedicated autosampler for automated operation and improved reproducibility.
Buffer flow is precisely controlled by an integrated peristaltic pump, providing stable flow rates from 10 µL/min to 400 µL/min to accommodate a wide range of experimental conditions. Typical sample volumes range from 200 to 500 µL, with the flexibility to accommodate larger or smaller volumes by selecting different sample loop sizes, helping to optimize sample consumption for diverse applications.
Flow cells
The MP-SPR Navi™ 200 OTSO is equipped with a standard two-channel PDMS flow cell with a low internal volume of 1 µL, minimizing sample consumption while enabling rapid exchange of solutions. To support a wide range of research applications, the system is compatible with several optional flow cells, including electrochemical, high chemical-resistance PEEK, gas, cell culture, and fluorescence flow cells. Custom flow cell designs are also available to meet specialized experimental requirements.
The versatile flow cell platform allows measurements in both liquid and gas environments and is compatible with aqueous solutions as well as selected organic solvents, including ethanol and acetonitrile. This flexibility enables researchers to perform molecular interaction studies, thin film characterization, electrochemical experiments, and in situ analyses across a broad range of life science, materials science, and surface engineering applications.
MP-SPR Navi 200 OTSO
Sensors & Substrates
MP-SPR Sensors
The MP-SPR Navi™ 200 OTSO supports a broad selection of sensor surfaces to accommodate diverse application requirements. Available sensor coatings include metals such as gold (Au), silver (Ag), copper (Cu), and platinum (Pt); inorganic materials including silicon dioxide (SiO₂), aluminum oxide (Al₂O₃), and titanium dioxide (TiO₂); as well as functionalized surfaces such as carboxymethyl dextran (CMD) and Ni²⁺-modified sensors for biomolecular interaction studies.
The system’s sensor holder also supports ex situ surface preparation, allowing researchers to deposit custom thin films or coatings using techniques such as spin coating before measurement. This flexibility enables the characterization of user-defined materials and expands the range of applications in surface science, biomaterials, coatings, and nanomaterials research.
Unique Regenerable Avidin – Kit
Revolutionizing regenerable avidin kit allows reversible binding of biotinylated ligands and thus same sensor slide can be used to measure interaction of multiple ligand molecules.
MP-SPR Navi 200 OTSO
Applications
Biosensor development
The MP-SPR platform provides a flexible, label-free solution for developing and optimizing assays and biosensors across a wide range of applications. Its highly sensitive measurements and customizable sensor surfaces enable the analysis of molecular interactions in both purified and complex samples, including serum, saliva, urine, and seawater. By combining MP-SPR with electrochemical techniques such as potentiometry, amperometry, and electrochemical impedance spectroscopy (EIS), researchers can simultaneously acquire complementary optical and electrochemical data from the same sensor surface. Intuitive software and advanced data analysis tools streamline assay development, surface optimization, and method validation, helping accelerate innovation in biosensing, diagnostics, and materials science.
Layers and coatings
Multi-Parametric Surface Plasmon Resonance (MP-SPR) enables simultaneous, real-time measurement of thin film thickness and refractive index with sub-nanometer sensitivity. By combining a wide angular scanning range with multi-wavelength measurements, the system accurately characterizes nanolayers from a few angstroms to several micrometers thick while monitoring adsorption and layer formation processes. MP-SPR helps researchers optimize coating processes, evaluate film quality and uniformity, monitor nanoparticle assembly, and study layer responses to changes in gas, humidity, or liquid environments.
Nanoparticles
Multi-Parametric Surface Plasmon Resonance (MP-SPR) enables label-free, real-time characterization of nanoparticle interactions while preserving the native properties of the nanoparticles. It provides highly sensitive measurements of nanoparticle binding kinetics, drug release, and interactions with biological targets, making it an ideal tool for developing nanoparticle-based drug delivery systems and contrast agents. By delivering quantitative, real-time data under biologically relevant conditions, MP-SPR helps researchers optimize nanoparticle formulations, improve targeting performance, and accelerate nanomedicine research.
Biomaterials
Multi-Parametric Surface Plasmon Resonance (MP-SPR) enables comprehensive characterization of biomaterials and soft materials by measuring film thickness, refractive index, swelling behavior, biofouling resistance, and interaction kinetics in real-time. The technique supports measurements in both wet and dry environments under controlled pH, temperature, and electrical conditions, making it well suited for physiologically relevant studies. MP-SPR also monitors layer-by-layer assembly and long-term changes in surface properties, helping researchers evaluate material stability, degradation, and performance for biomedical and advanced materials applications.