BioNavis MP-SPR
MP-SPR Navi 210A VASA
automated 2 channel system for vials
The MP-SPR Navi™ 210A VASA is a fully automated Multi-Parametric Surface Plasmon Resonance (MP-SPR) system designed for precise, real-time characterization of molecular interactions and thin film properties. Engineered for high reproducibility and ease of operation, the system automates measurements to deliver consistent, high-quality data while minimizing user intervention. Its two-channel configuration, combined with support for up to four laser wavelengths, enables comprehensive analysis of adsorption, binding kinetics, film thickness, and optical properties across a wide range of materials research, surface science, and biosensing applications.
2 Channels, 4 Wavelengths
Simultaneously measure in 2 channels on one sensor. Use up to 4 different wavelengths in each channel
Automation Operation
User-friendly automation with integrated degassing routines allows for unattended measurements from 6 samples.
Add on Modules
Complement with electrochemical, high chemical resistant, cell, fluorescence and gas flow modules
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automated 2 channel system for vials
The MP-SPR Navi™ 210A VASA is a fully automated Multi-Parametric Surface Plasmon Resonance (MP-SPR) system designed for high-precision material characterization, nanoparticle research, and biomolecular interaction analysis. By combining complete SPR curve acquisition, multi-wavelength measurements, and automated six-sample liquid handling, the system delivers comprehensive characterization of molecular interactions, thin films, and surface properties with minimal user intervention. The MP-SPR Navi™ 210A VASA features intuitive software, simplified sensor handling, and integrated degassing to enable reliable, unattended operation. The system performs simultaneous measurements in two independent flow channels and can be configured with up to four laser wavelengths per channel. A high chemical-resistance flow cell with wide-bore tubing is compatible with organic solvents and complex samples, making the MP-SPR Navi™ 210A VASA a versatile platform for demanding research in life sciences, nanotechnology, and advanced materials research.
Application Areas:
MP-SPR Navi 210A VASA
Product Features
Angular scanning mode
The MP-SPR Navi™ 210A VASA employs a true goniometric Surface Plasmon Resonance (SPR) configuration with a rotating detector to perform angular scanning, known as MP-SPR mode. Instead of measuring at a single angle, the system scans across a wide angular range of 40° to 78°, capturing the complete SPR curve with an exceptional angular resolution of 0.001°. This comprehensive measurement provides access to multiple analytical parameters beyond those available with conventional SPR systems, enabling more detailed characterization of molecular interactions and thin films. Typical sampling rates are less than two seconds, depending on the selected angular range and resolution, allowing rapid, real-time monitoring of dynamic surface processes.
Laser Wavelengths
The MP-SPR Navi™ 210A VASA is equipped with a 670 nm laser as standard, enabling high-sensitivity measurements across both flow channels. For advanced applications, each channel can be configured with multiple wavelengths, including dual-laser (670 nm and 785 nm), triple-laser (670 nm, 785 nm, and 980 nm), or quad-laser (670 nm, 785 nm, 850 nm, and 980 nm) configurations. The additional laser wavelengths provide multi-wavelength MP-SPR measurements that enable the detection of molecular conformational changes and the characterization of thin film properties, including layer thickness, refractive index, and structural evolution, extending the system beyond traditional interaction analysis. This feature is critical in applications involving layer characterization, live cell studies, and extracellular vesicle size and concentration analysis.
Liquid handling
The MP-SPR Navi™ 210A VASA features an automated liquid handling system designed to increase throughput, improve reproducibility, and enable unattended MP-SPR experiments. The system accommodates up to six different samples for sequential automated analysis and features two independent flow channels with software-controlled selection of serial or parallel sample injections.
Buffer delivery is precisely controlled using high-accuracy syringe pumps and an integrated degasser, ensuring stable, pulse-free flow conditions for reliable kinetic measurements. The system supports flow rates from 1 µL/min to 1,000 µL/min, providing the flexibility required for a wide range of biomolecular interaction studies, surface characterization experiments, and assay development workflows.
Flow cells
The MP-SPR Navi™ 210A VASA is equipped with a standard high chemical resistant PEEK flow cell with wider tubing diameter which is optimal for material science research. It has a low internal volume of 1 µL, minimizing sample consumption while enabling rapid exchange of solutions. To support a wide range of research applications, the system is compatible with several optional flow cells, including electrochemical, gas, cell culture, and fluorescence flow cells. Custom flow cell designs are also available to meet specialized experimental requirements.
The versatile flow cell platform allows measurements in both liquid and gas environments and is compatible with aqueous solutions as well as selected organic solvents, including ethanol and acetonitrile. This flexibility enables researchers to perform molecular interaction studies, thin film characterization, electrochemical experiments, and in situ analyses across a broad range of life science, materials science, and surface engineering applications.
MP-SPR Navi 210A VASA
Sensors & Substrates
MP-SPR Sensors
The MP-SPR Navi™ 210A VASA supports a broad selection of sensor surfaces to accommodate diverse application requirements. Available sensor coatings include metals such as gold (Au), silver (Ag), copper (Cu), and platinum (Pt); inorganic materials including silicon dioxide (SiO₂), aluminum oxide (Al₂O₃), and titanium dioxide (TiO₂); as well as functionalized surfaces such as carboxymethyl dextran (CMD) and Ni²⁺-modified sensors for biomolecular interaction studies.
The system’s sensor holder also supports ex situ surface preparation, allowing researchers to deposit custom thin films or coatings using techniques such as spin coating before measurement. This flexibility enables the characterization of user-defined materials and expands the range of applications in surface science, biomaterials, coatings, and nanomaterials research.
Unique Regenerable Avidin – Kit
Revolutionizing regenerable avidin kit allows reversible binding of biotinylated ligands and thus same sensor slide can be used to measure interaction of multiple ligand molecules.
MP-SPR Navi 210A VASA
Applications
Biosensor development
The MP-SPR platform provides a flexible, label-free solution for developing and optimizing assays and biosensors across a wide range of applications. Its highly sensitive measurements and customizable sensor surfaces enable the analysis of molecular interactions in both purified and complex samples, including serum, saliva, urine, and seawater. By combining MP-SPR with electrochemical techniques such as potentiometry, amperometry, and electrochemical impedance spectroscopy (EIS), researchers can simultaneously acquire complementary optical and electrochemical data from the same sensor surface. Intuitive software and advanced data analysis tools streamline assay development, surface optimization, and method validation, helping accelerate innovation in biosensing, diagnostics, and materials science.
Layers and coatings
Multi-Parametric Surface Plasmon Resonance (MP-SPR) enables simultaneous, real-time measurement of thin film thickness and refractive index with sub-nanometer sensitivity. By combining a wide angular scanning range with multi-wavelength measurements, the system accurately characterizes nanolayers from a few angstroms to several micrometers thick while monitoring adsorption and layer formation processes. MP-SPR helps researchers optimize coating processes, evaluate film quality and uniformity, monitor nanoparticle assembly, and study layer responses to changes in gas, humidity, or liquid environments.
Nanoparticles
Multi-Parametric Surface Plasmon Resonance (MP-SPR) enables label-free, real-time characterization of nanoparticle interactions while preserving the native properties of the nanoparticles. It provides highly sensitive measurements of nanoparticle binding kinetics, drug release, and interactions with biological targets, making it an ideal tool for developing nanoparticle-based drug delivery systems and contrast agents. By delivering quantitative, real-time data under biologically relevant conditions, MP-SPR helps researchers optimize nanoparticle formulations, improve targeting performance, and accelerate nanomedicine research.
Biomaterials
Multi-Parametric Surface Plasmon Resonance (MP-SPR) enables comprehensive characterization of biomaterials and soft materials by measuring film thickness, refractive index, swelling behavior, biofouling resistance, and interaction kinetics in real-time. The technique supports measurements in both wet and dry environments under controlled pH, temperature, and electrical conditions, making it well suited for physiologically relevant studies. MP-SPR also monitors layer-by-layer assembly and long-term changes in surface properties, helping researchers evaluate material stability, degradation, and performance for biomedical and advanced materials applications.
Molecular Interactions
Multi-Parametric Surface Plasmon Resonance (MP-SPR) is a highly sensitive, label-free technology for studying molecular interactions across a broad range of analytes, including proteins, peptides, nucleic acids, small-molecule drugs, viruses, nanoparticles, living cells, and bacteria. The technique provides accurate, real-time measurements of binding affinity, kinetic rate constants, and bound mass for interactions such as antibody-antigen, receptor-ligand, and drug-target binding. Unlike conventional SPR, MP-SPR can directly analyze interactions in complex biological matrices, including 100% serum, plasma, saliva, and other physiologically relevant fluids. Its unique PureKinetics™ technology uses complete SPR curve measurements to continuously correct for changes in the bulk refractive index (bulk effect) within each measurement channel. This real-time correction eliminates the need for a dedicated reference channel for bulk compensation, improving the accuracy of kinetic measurements in crude samples. MP-SPR also enables the characterization of membrane-associated interactions by accurately measuring binding events involving liposomes, membrane extracts, and living cells. This capability allows researchers to investigate biomolecular interactions under conditions that closely mimic their native biological environment.
Biocompatibility
Multi-Parametric Surface Plasmon Resonance (MP-SPR) enables label-free, real-time characterization of biomolecular interactions in clinically relevant complex media, including serum, plasma, urine, bacterial suspensions, and cell culture media. This capability makes MP-SPR particularly valuable for biocompatibility and biointerface research, including the evaluation of antifouling coatings for medical devices and characterization of protein corona formation on nanoparticle drug carriers. Unlike conventional SPR, where changes in sample composition can produce significant bulk refractive index effects, MP-SPR simultaneously measures multiple optical parameters through its unique goniometric optical configuration. Using PureKinetics™, these parameters are correlated in real-time to correct for bulk effects, enabling accurate kinetic analysis even in complex biological samples.